Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2-Reference-Cited by-同舟云学术

Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2

Published:2022-08-18 Issue:9 Volume:13 Page:1485-1492
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Niwa Hideaki¹²^ORCID,Watanabe Chiduru³^ORCID,Sato Shin¹²,Harada Toshiyuki³,Watanabe Hisami¹²,Tabusa Ryo⁴,Fukasawa Shunsuke⁴,Shiobara Ayane⁴,Hashimoto Tomoko⁴,Ohno Osamu⁴^ORCID,Nakamura Kana²,Tsuganezawa Keiko²,Tanaka Akiko²,Shirouzu Mikako²,Honma Teruki³^ORCID,Matsuno Kenji⁴⁵^ORCID,Umehara Takashi¹²^ORCID

Affiliation:

1. Laboratory for Epigenetics Drug Discovery, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

2. Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

3. Drug Discovery Computational Chemistry Platform Unit, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

4. Laboratory of Medicinal Chemistry, Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano, Hachioji, Tokyo 192-0015, Japan

5. Department of Pharmacy, Faculty of Pharmacy, Yasuda Women’s University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00294

Reference25 articles.

1. Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases