Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12-Reference-Cited by-同舟云学术

Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12

Published:2024-09-10 Issue: Volume: Page:
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Lewis Timothy A.¹^ORCID,Ellermann Manuel²,Kopitz Charlotte²,Lange Martin²^ORCID,de Waal Luc³⁴,Wu Xiaoyun³,Tersteegen Adrian⁵,Denner Karsten²,Lienau Philip²,Kaulfuss Stefan²,Goldoni Silvia⁶,Meyerson Matthew³⁴,Greulich Heidi³⁴,Gradl Stefan N.²

Affiliation:

1. Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States

2. Bayer AG, Berlin 13353, Germany

3. Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States

4. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 01255, United States

5. Bayer AG, Wuppertal 42096, Germany

6. Research and Early Development Oncology, Bayer Pharmaceuticals, Cambridge, Massachusetts 02142, United States

Funder

Pharmaceuticals Bayer

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00336

Reference17 articles.

1. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

2. Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12

3. Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

4. Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells

5. Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death