Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group-Reference-Cited by-同舟云学术

Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group

Published:2016-05-11 Issue:7 Volume:7 Page:702-707
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Bungard Christopher J.¹,Williams Peter D.¹,Ballard Jeanine E.¹,Bennett David J.¹,Beaulieu Christian²,Bahnck-Teets Carolyn¹,Carroll Steve S.¹,Chang Ronald K.¹,Dubost David C.¹,Fay John F.¹,Diamond Tracy L.¹,Greshock Thomas J.¹,Hao Li³,Holloway M. Katharine¹,Felock Peter J.,Gesell Jennifer J.¹,Su Hua-Poo¹,Manikowski Jesse J.¹,McKay Daniel J.²,Miller Mike¹,Min Xu¹,Molinaro Carmela¹,Moradei Oscar M.²,Nantermet Philippe G.¹,Nadeau Christian²,Sanchez Rosa I.¹,Satyanarayana Tummanapalli³,Shipe William D.¹,Singh Sanjay K.³,Truong Vouy Linh²,Vijayasaradhi Sivalenka³,Wiscount Catherine M.¹,Vacca Joseph P.²,Crane Sheldon N.²,McCauley John A.¹

Affiliation:

1. Merck Research Laboratories, 770 Sumneytown Pike, PO Box 4, West Point, Pennsylvania 19486, United States

2. Merck Frosst Centre for Therapeutic Research, 16711 TransCanada Highway, Kirkland, Quebec H9H 3L1, Canada

3. Albany Molecular Research Singapore Research Center, 61 Science Park Road #05-01, The Galen Singapore Science Park II, Singapore 117525

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00135

Reference26 articles.

1. Cleavage of HIV-1gagPolyprotein Synthesized In Vitro: Sequential Cleavage by the Viral Protease

2. Active human immunodeficiency virus protease is required for viral infectivity.

3. Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance

4. Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS

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