Design, Synthesis, and Evaluation of PD-1/PD-L1 Antagonists Bearing a Benzamide Scaffold-Reference-Cited by-同舟云学术

Design, Synthesis, and Evaluation of PD-1/PD-L1 Antagonists Bearing a Benzamide Scaffold

Published:2022-03-29 Issue:4 Volume:13 Page:586-592
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Lu Lu¹,Qi Zhihao¹,Wang Tianyu¹,Zhang Xiangyu¹,Zhang Kuojun¹,Wang Kaizhen¹,Cheng Yao¹,Xiao Yibei¹,Li Zheng²,Jiang Sheng¹^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry and Department of Biomedical Engineering, China Pharmaceutical University, Nanjing 210009, China

2. Center for Bioenergetics, Houston Methodist Research Institute, 6670 Bertner, Houston, Texas 77030, United States

Funder

National Natural Science Foundation of China

Double First-Class University Project

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00646

Reference26 articles.

1. WHO Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All; World Health Organization: Geneva, Switzerland, 2020.

2. Mechanisms of immune escape in the cancer immune cycle

3. Immunomodulators targeting the PD-1/PD-L1 protein-protein interaction: From antibodies to small molecules

4. Progress in PD-1/PD-L1 pathway inhibitors: From biomacromolecules to small molecules

5. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies

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