Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma-Reference-Cited by-同舟云学术

Rational Design, Optimization, and Biological Evaluation of Novel MEK4 Inhibitors against Pancreatic Adenocarcinoma

Published:2021-09-15 Issue:10 Volume:12 Page:1559-1567
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Kwong Ada J.¹^ORCID,Pham Thao N. D.²,Oelschlager Hannah E.¹,Munshi Hidayatullah G.²,Scheidt Karl A.¹^ORCID

Affiliation:

1. Department of Chemistry, Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States

2. Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 E. Superior Street, Chicago, Illinois 60611, United States

Funder

National Cancer Institute

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00376

Reference32 articles.

1. MAPK signal pathways in the regulation of cell proliferation in mammalian cells

2. Differential regulation and properties of MAPKs

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4. Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

5. MEK and the inhibitors: from bench to bedside

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