Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase-Reference-Cited by-全球学者库

Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase

Published:2021-11-15 Issue:12 Volume:12 Page:1962-1967
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Bheemanaboina Rammohan R. Yadav¹,de Souza Mariana Laureano²,Gonzalez Mariana Lozano¹,Mahmood Shams Ul¹,Eck Tyler¹,Kreiss Tamara¹,Aylor Samantha O.³,Roth Alison³,Lee Patricia³,Pybus Brandon S.³,Colussi Dennis J.⁴,Childers Wayne E.⁴,Gordon John⁴,Siekierka John J.¹,Bhanot Purnima²,Rotella David P.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry and Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States

2. Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, 225 Warren Street, Newark, New Jersey 07103, United States

3. Department of Drug Discovery, Experimental Therapeutics Branch, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, United States

4. Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States

Funder

Margaret and Herman Sokol Institute for Pharmaceutical Life Sciences, Montclair State University

National Institute of Allergy and Infectious Diseases

U.S. Department of Defense

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00540

Reference18 articles.

1. Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

2. Association of Plasmodium falciparum kelch13 R561H genotypes with delayed parasite clearance in Rwanda: an open-label, single-arm, multicentre, therapeutic efficacy study

3. World Malaria Report 2018; World Health Organization, 2018.

4. Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

5. New developments in anti-malarial target candidate and product profiles

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