Fragment-Based Discovery of Novel Allosteric MEK1 Binders-Reference-Cited by-同舟云学术

Fragment-Based Discovery of Novel Allosteric MEK1 Binders

Published:2021-01-27 Issue:2 Volume:12 Page:302-308
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Di Fruscia Paolo¹^ORCID,Edfeldt Fredrik²,Shamovsky Igor³^ORCID,Collie Gavin W.¹^ORCID,Aagaard Anna²,Barlind Louise⁴,Börjesson Ulf²,Hansson Eva L.⁵,Lewis Richard J.³^ORCID,Nilsson Magnus K.³,Öster Linda²,Pemberton Josefine²,Ripa Lena³^ORCID,Storer R. Ian¹,Käck Helena²^ORCID

Affiliation:

1. Structure Biophysics & Fragments, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom

2. Structure Biophysics & Fragments, Discovery Sciences, R&D, AstraZeneca, Gothenburg 431 83, Sweden

3. Medicinal Chemistry, Research & Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg 431 83, Sweden

4. Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg 431 83, Sweden

5. Mechanistic Biology and Profiling, Discovery Sciences, R&D, AstraZeneca, Gothenburg 431 83, Sweden

Funder

Pharmaron

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.0c00563

Reference28 articles.

1. Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973)

2. Pathological roles of MAPK signaling pathways in human diseases

3. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

4. MEK and the inhibitors: from bench to bedside

5. MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road

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