Chemical Catalysis Guides Structural Identification for the Major <i>In Vivo</i> Metabolite of the BET Inhibitor JQ1-Reference-Cited by-同舟云学术

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Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1

Published:2024-01-02 Issue:1 Volume:15 Page:107-115
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Holmes Secondra¹²,Jain Prashi¹²,Rodriguez Kenneth Guzman¹²^ORCID,Williams Jade¹²,Yu Zhifeng¹²,Cerda-Smith Christian¹,Samuel Errol L. G.¹,Campbell James¹,Hakenjos John Michael¹,Monsivais Diana¹,Li Feng¹,Chamakuri Srinivas¹,Matzuk Martin M.¹^ORCID,Santini Conrad¹,MacKenzie Kevin R.¹²,Young Damian W.¹²^ORCID

Affiliation:

1. Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, Texas 77030, United States

2. Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States

Funder

Welch Foundation

Baylor College of Medicine

Bill and Melinda Gates Foundation

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00464

Reference41 articles.

1. BET Inhibitors as Anticancer Agents: A Patent Review

2. BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

3. Drug Discovery Targeting Bromodomain-Containing Protein 4

4. BET Proteins as Targets for Anticancer Treatment

5. Small-Molecule Inhibition of BRDT for Male Contraception

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