Atypical <i>N</i>-Alkyl to <i>N</i>-Noralkoxy Switch in a Dual cSRC/BCR-ABL1 Kinase Inhibitor Improves Drug Efflux and hERG Affinity-Reference-Cited by-同舟云学术

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Atypical N-Alkyl to N-Noralkoxy Switch in a Dual cSRC/BCR-ABL1 Kinase Inhibitor Improves Drug Efflux and hERG Affinity

Published:2023-12-05 Issue:12 Volume:14 Page:1869-1875
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Hill Jarvis¹²^ORCID,Jones Robert M.³,Crich David¹²⁴^ORCID

Affiliation:

1. Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, United States

2. Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States

3. Independent Researcher, P.O. Box 568, Oakley, Utah 84055-0568, United States

4. Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States

Funder

Georgia Research Alliance

University of Georgia

Natural Sciences and Engineering Research Council of Canada

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00479

Reference53 articles.

1. Discovery of a Hydroxylamine-Based Brain-Penetrant EGFR Inhibitor for Metastatic Non-Small-Cell Lung Cancer

2. The N,N,O-Trisubstituted Hydroxylamine Isostere and Its Influence on Lipophilicity and Related Parameters

3. Enzymatic phase II activation of the N-hydroxylamines of IQ, MelQx and PhIP by various organs of monkeys and rats

4. Metabolic activation of heterocyclic amine food mutagens in the mammary gland of lactating Fischer 344 rats

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