Novel Triazolopyridine-Based BRD4 Inhibitors as Potent HIV-1 Latency Reversing Agents

Author:

Wang Yan-Kai1,Huang Xu-Sheng23,Sun Hao1,Ma Meng-Di23,Yu Hai-Peng4,Hu Wei4,Li Zhi-Yu5ORCID,Li Zhong4,Luo Rong-Hua2,Tian Ren-Rong2,Xiao Tai-Fu6,Yang Liu-Meng2,Zheng Yong-Tang2,Li Xun1ORCID

Affiliation:

1. School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, National Key Laboratory of Advanced Drug Delivery System, Key Laboratory for Biotechnology Drugs of National Health Commission (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Jinan 250117, Shandong, China

2. Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Science and Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. Shandong University, No. 72 Binhai Road, Qingdao 266237, China

5. Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, Department of Chemistry & Biochemistry, Misher College of Arts and Sciences, University of the Sciences, 600 South 43rd Street, Philadelphia, Pennsylvania 19104, United States

6. Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan, China

Funder

Yunnan Key Research and Development Program

National Key Research and Development Program of China

Shandong First Medical University

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Project of Innovative Research Team of Yunnan Province

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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