ZX703: A Small-Molecule Degrader of GPX4 Inducing Ferroptosis in Human Cancer Cells-Reference-Cited by-同舟云学术

ZX703: A Small-Molecule Degrader of GPX4 Inducing Ferroptosis in Human Cancer Cells

Published:2024-02-15 Issue:3 Volume:15 Page:406-412
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Hu Mengdie¹,Li Xiaomei²,Wang Lin¹,Zhang Yanping¹,Sun Yujie²,Hua Hui²,Liu Huina²,Cai Ting²,Zhu Dongsheng¹,Xiang Qiuping²^ORCID

Affiliation:

1. Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, and Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China

2. Guoke Ningbo Life Science and Health Industry Research Institute, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315000, China

Funder

National Natural Science Foundation of China

Ningbo Yongjiang Talent Introduction Programme

octoral Program of Entrepreneurship and Innovation in Jiangsu Province

Ningbo Medical Key Discipline

Zhu Xiu Shan Talent Project of Ningbo No.2 Hospital

Ningbo Natural Science Foundation

Natural Science Foundation of the Jiangsu Higher Education Institutions of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00571

Reference31 articles.

1. Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

2. Regulation of Ferroptotic Cancer Cell Death by GPX4

3. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

4. Synchronized renal tubular cell death involves ferroptosis

5. The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents

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1. Design, synthesis, and biological evaluation of RSL3-based GPX4 degraders with hydrophobic tags;European Journal of Medicinal Chemistry;2024-11

2. Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches;Drug Design, Development and Therapy;2024-06