An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors-Reference-Cited by-同舟云学术

An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors

Published:2019-01-30 Issue:2 Volume:10 Page:215-220
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Wilson Tyler A.¹,Koneru Pratibha C.²,Rebensburg Stephanie V.²,Lindenberger Jared J.²,Kobe Matthew J.³,Cockroft Nicholas T.¹,Adu-Ampratwum Daniel¹,Larue Ross C.³,Kvaratskhelia Mamuka²,Fuchs James R.¹^ORCID

Affiliation:

1. Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States

2. Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado 80045, United States

3. Division of Pharmaceutics & Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, United States

Funder

National Center for Advancing Translational Sciences

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00633

Reference28 articles.

1. HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis

2. Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

3. Strand transfer inhibitors of HIV-1 integrase: Bringing IN a new era of antiretroviral therapy

4. Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

5. Multiple choices for HIV therapy with integrase strand transfer inhibitors

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Direct Assembly of Vinyl Fluorinated Isoquinolines Via Rh(III)-Catalyzed [4 + 2] Annulation;The Journal of Organic Chemistry;2023-07-17

2. Quinolines and isoquinolines as HIV-1 inhibitors: Chemical structures, action targets, and biological activities;Bioorganic Chemistry;2023-07

3. Recent Developments in the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors Incorporating Pyridine Moiety;International Journal of Molecular Sciences;2023-05-26

4. Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 Å resolution: Routes to inhibitor optimization;PLOS Pathogens;2023-03-03

5. Human immunodeficiency virus integration complexes are active following ordered addition of wild type integrase, viral DNA, and LEDGF/p75;2022-09-19