Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core-Reference-Cited by-同舟云学术

Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core

Published:2017-08-18 Issue:9 Volume:8 Page:919-924
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Bollinger Katrina A.¹,Felts Andrew S.²¹,Brassard Christopher J.²¹,Engers Julie L.²¹,Rodriguez Alice L.²¹,Weiner Rebecca L.¹,Cho Hyekyung P.²¹,Chang Sichen¹,Bubser Michael²¹,Jones Carrie K.²¹³,Blobaum Anna L.²¹,Niswender Colleen M.²¹³,Conn P. Jeffrey²¹³,Emmitte Kyle A.²⁴¹^ORCID,Lindsley Craig W.²⁴¹^ORCID

Affiliation:

1. Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

2. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

3. Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States

4. Department of Chemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

Funder

William K. Warren Foundation

National Institute of Mental Health

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00279

Reference26 articles.

1. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

2. Immunohistochemical localization of metabotropic glutamate receptors mGluR1a and mGluR2/3 in the rat basal ganglia

3. Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat

4. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex

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