Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N′-arylpiperazine Series-Reference-Cited by-同舟云学术

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N′-arylpiperazine Series

Published:2014-03-31 Issue:7 Volume:57 Page:3094-3116
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nishimura Nobuko¹,Norman Mark H.¹,Liu Longbin¹,Yang Kevin C.¹,Ashton Kate S.¹,Bartberger Michael D.¹,Chmait Samer¹,Chen Jie¹,Cupples Rod¹,Fotsch Christopher¹,Helmering Joan¹,Jordan Steven R.¹,Kunz Roxanne K.¹,Pennington Lewis D.¹,Poon Steve F.¹,Siegmund Aaron¹,Sivits Glenn¹,Lloyd David J.¹,Hale Clarence¹,St. Jean David J.¹

Affiliation:

1. Department of Therapeutic Discovery—Medicinal Chemistry, ‡Department of Therapeutic Discovery—Molecular Structure and Characterization, §Department of Metabolic Disorders, and ∥Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1799, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm5000497

Reference24 articles.

1. International Diabetes Federation. IDF Diabetes Atlas.http://www.idf.org/(accessed Aug 13, 2013) .

2. Novel Pharmacological Approaches to the Treatment of Type 2 Diabetes

3. Glucokinase Activators for Diabetes Therapy

4. GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?

5. Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Cited by 50 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Iron-Catalyzed Photochemical Synthesis of Sulfinamides from Aliphatic Hydrocarbons and Sulfinylamines;Organic Letters;2024-04-26

2. Current Insight on the Role of Glucokinase and Glucokinase Regulatory Protein in Diabetes;Mini-Reviews in Medicinal Chemistry;2024-04

3. S_NAr or Sulfonylation? Chemoselective Amination of Halo(het)arene Sulfonyl Halides for Synthetic Applications and Ultralarge Compound Library Design;The Journal of Organic Chemistry;2024-02-21

4. Rh(iii)-catalyzed redox-neutral C–H [4 + 1] annulation of sulfoximines with α,α-difluoromethylene alkynes: diastereoselective synthesis of E-monofluoroalkenyl benzoisothiazole 1-oxides;Organic Chemistry Frontiers;2023

5. N-Cyano sulfilimine functional group as a nonclassical amide bond bioisostere in the design of a potent analogue to anthranilic diamide insecticide;RSC Advances;2023