Novel C-Terminus Modifications of the Dmt-Tic Motif: A New Class of Dipeptide Analogues Showing Altered Pharmacological Profiles Toward the Opioid Receptors
Author:
Affiliation:
1. Departments of Chemistry and Pharmacology, AstraZeneca R&D Montreal, 7171 Frederick-Banting, Saint-Laurent, Quebec, Canada H4S 1Z9
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm015532k
Reference32 articles.
1. Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.
2. (b) Schiller, P. W.; Nguyen, T. M.D.; Weltrowska, G.; Wilkes, B. C.; Marsden, J.; Schmidt, R.; Lemieux, C.; Chung, N. N. TIPP opioid peptides: development of extraordinarily potent and selective opioid δ antagonists and observation of astonishing structure-intrinsic activity relationships.Peptides; Hodges, R. S., Smith, J. A., Eds; ESCOM: Leiden, The Netherlands, 1994; pp 483−486.
3. δ Opioidmimetic Antagonists: Prototypes for Designing a New Generation of Ultraselective Opioid Peptides
4. Suppression of immune function by non-peptidic delta opioid receptor antagonists
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