1. Functional Food Research and Development Laboratory, Meiji Seika Kaisha, Ltd., 5-3-1 Chiyoda, Sakadoshi, Saitama, Japan; Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama, Kanagawa, Japan; and Department of Applied Biological Science, Nagoya University, Chikusa, Nagoya, Aichi, Japan