Synthesis, Structure–Activity Relationship, and Pharmacological Studies of Novel Melanin-Concentrating Hormone Receptor 1 Antagonists 3-Aminomethylquinolines: Reducing Human Ether-a-go-go-Related Gene (hERG) Associated Liabilities-Reference-Cited by-同舟云学术

Synthesis, Structure–Activity Relationship, and Pharmacological Studies of Novel Melanin-Concentrating Hormone Receptor 1 Antagonists 3-Aminomethylquinolines: Reducing Human Ether-a-go-go-Related Gene (hERG) Associated Liabilities

Published:2012-04-23 Issue:9 Volume:55 Page:4336-4351
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kasai Shizuo¹,Kamata Makoto¹,Masada Shinichi¹,Kunitomo Jun¹,Kamaura Masahiro¹,Okawa Tomohiro¹,Takami Kazuaki¹,Ogino Hitomi¹,Nakano Yoshihide¹,Ashina Shuntarou¹,Watanabe Kaoru¹,Kaisho Tomoko¹,Imai Yumi N.¹,Ryu Sunghi¹,Nakayama Masaharu¹,Nagisa Yasutaka¹,Takekawa Shiro¹,Kato Koki¹,Murata Toshiki¹,Suzuki Nobuhiro¹,Ishihara Yuji¹

Affiliation:

1. Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd., 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300167z

Reference52 articles.

1. Isolation and Identification of Melanin-Concentrating Hormone as the Endogenous Ligand of the SLC-1 Receptor

2. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1

3. Molecular characterization of the melanin-concentrating-hormone receptor

4. The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor

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