Structure Elucidation Via Stereoselective Synthesis of the Acetate Center of 1-Azabicyclo[2.2.2]oct-3-yl α-Hydroxy- α-(1-iodo-1-propen-3-yl)-α-phenylacetate (IQNP). A High Affinity Muscarinic Imaging Agent for SPECT-Reference-Cited by-同舟云学术

Structure Elucidation Via Stereoselective Synthesis of the Acetate Center of 1-Azabicyclo[2.2.2]oct-3-yl α-Hydroxy- α-(1-iodo-1-propen-3-yl)-α-phenylacetate (IQNP). A High Affinity Muscarinic Imaging Agent for SPECT

Published:1996-11-15 Issue:23 Volume:61 Page:8335-8337
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

McPherson Daniel W.¹,Knapp Furn F.¹

Affiliation:

1. Nuclear Medicine Group, Health Sciences Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6229

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo961033t

Reference9 articles.

1. Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl .alpha.-hydroxy-.alpha.-(1-iodo-1-propen-3-yl)-.alpha.-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography

2. Resolution and in Vitro and Initial in Vivo Evaluation of Isomers of Iodine-125-Labeled 1-Azabicyclo[2.2.2]oct-3-yl .alpha.-Hydroxy-.alpha.-(1-iodo-1-propen-3-yl)-.alpha.-phenylacetate: A High-Affinity Ligand for the Muscarinic Receptor

3. In vivo metabolic studies of thetrans-(R,R) isomer of radioiodinated IQNP: A new ligand with high affinity for the M1 muscarinic-cholinergic receptor

4. Characterization of in vivo brain muscarinic acetylcholine receptor subtype selectivity by competition studies against (R,S)-[125I]QNB

5. Absolute configuration of 3-quinuclidinyl benzilate and the behavioral effect in the dog of the optical isomers

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