How Well Can Fragments Explore Accessed Chemical Space? A Case Study from Heat Shock Protein 90

Author:

Roughley Stephen D.1,Hubbard Roderick E.12

Affiliation:

1. Vernalis (R&D) Ltd., Granta Park, Abington, Cambridge, CB21 6GB, U.K.

2. York Structural Biology Laboratory and Hull York Medical School, University of York, Heslington, York, YO10 5DD, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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3. Pan‐HSP90 ligand binding reveals isoform‐specific differences in plasticity and water networks;Protein Science;2023-04-17

4. Fragment-based Ligand Discovery (FBLD);The Handbook of Medicinal Chemistry;2023-02-03

5. Chemical evolution of natural product structure for drug discovery;Annual Reports in Medicinal Chemistry;2023

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