Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists-Reference-Cited by-同舟云学术

Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists

Published:2024-03-11 Issue:5 Volume:10 Page:956-968
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Kosar Miroslav¹^ORCID,Sarott Roman C.¹^ORCID,Sykes David A.²³,Viray Alexander E. G.⁴,Vitale Rosa Maria⁵^ORCID,Tomašević Nataša⁶,Li Xiaoting⁷,Ganzoni Rudolf L. Z.¹,Kicin Bilal¹^ORCID,Reichert Lisa¹,Patej Kacper J.¹,Gómez-Bouzó Uxía¹,Guba Wolfgang⁸^ORCID,McCormick Peter J.⁹,Hua Tian⁷,Gruber Christian W.⁶^ORCID,Veprintsev Dmitry B.²³^ORCID,Frank James A.⁴¹⁰^ORCID,Grether Uwe⁸^ORCID,Carreira Erick M.¹^ORCID

Affiliation:

1. Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland

2. Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.

3. Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham,

4. Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon 97239-3098, United States

5. Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli, Italy

6. Center for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria

7. iHuman Institute, ShanghaiTech University, Shanghai 201210, China

8. Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland

9. Department of Pharmacology and Therapeutics, University of Liverpool, Ashton Street, Liverpool L69 3GE, U.K.

10. Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239-3098, United States

Funder

Roche

Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung

National Key Research and Development Program of China

Ministero dell?Istruzione, dell?Universit? e della Ricerca

European Cooperation in Science and Technology

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.3c01461

Reference84 articles.

1. Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years

2. Molecular characterization of a peripheral receptor for cannabinoids

3. Cannabinoid receptors as therapeutic targets for autoimmune diseases: where do we stand?

4. Role of Cannabinoids in Obesity

5. Therapeutic potential of cannabinoid receptor 2 in the treatment of diabetes mellitus and its complications

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