Mechanistic Insights into Tf<sub>2</sub>O-Promoted Electrophilic Activation of 2-Propynamides and a New Synthesis of 2,4-Disubstituted Quinolines-Reference-Cited by-同舟云学术

Mechanistic Insights into Tf₂O-Promoted Electrophilic Activation of 2-Propynamides and a New Synthesis of 2,4-Disubstituted Quinolines

Published:2022-11-28 Issue:48 Volume:24 Page:8806-8811
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Shan Lidong¹,Li Hongchen¹,Zheng Weiping¹,Wang Xingyong¹,Wang Xinyan¹^ORCID,Hu Yuefei¹^ORCID

Affiliation:

1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.2c03565

Reference40 articles.

1. Triflic Anhydride (Tf 2 O): An Efficient Catalyst for Electrophilic Activation of Amides

2. Amide activation: an emerging tool for chemoselective synthesis

3. Making the Least Reactive Electrophile the First in Class: Domino Electrophilic Activation of Amides

4. Metal-free synthesis of quinolines by direct condensation of amides with alkynes: revelation of N-aryl nitrilium intermediates by 2D NMR techniques

5. Spectroscopic studies of the electrophilic activation of amides with triflic anhydride and pyridine

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