Molecular Basis for the P450-Catalyzed sp3 C–N Glycosidic Bond Formation in Staurosporine Biosynthesis

Author:

Xiao Fei1,Zhou Tai-Ping2,Dong Sheng3,Li Tong1,Yun Cai-Hong4ORCID,Feng Yingang3ORCID,Cui Qiu5,Hong Kui6,Wang Binju2ORCID,Li Wenli178ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

2. State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China

3. CAS Key Laboratory of Biofuels and Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, CAS, Qingdao 266101, China

4. School of Basic Medical Sciences, Peking University, Beijing 100191, China

5. State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China

6. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Science, Wuhan University, Wuhan 430071, China

7. Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China

8. State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

American Chemical Society (ACS)

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