Understanding the Molecular Mechanism of the Ala-versus-Gly Concept Controlling the Product Specificity in Reactions Catalyzed by Lipoxygenases: A Combined Molecular Dynamics and QM/MM Study of Coral 8R-Lipoxygenase
Author:
Affiliation:
1. Department of Chemistry, King’s College London, London SE1 1DB, United Kingdom
2. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
Funder
Engineering and Physical Sciences Research Council
Ministerio de Econom?a y Competitividad
H2020 Marie Sklodowska-Curie Actions
Publisher
American Chemical Society (ACS)
Subject
Catalysis,General Chemistry
Link
http://pubs.acs.org/doi/pdf/10.1021/acscatal.7b00842
Reference63 articles.
1. Functional and pathological roles of the 12- and 15-lipoxygenases
2. Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease
3. Lipoxygenases: Potential starting biocatalysts for the synthesis of signaling compounds
4. The structural basis for specificity in lipoxygenase catalysis
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