One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts-Reference-Cited by-同舟云学术

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

Published:2016-05-12 Issue:6 Volume:6 Page:3753-3759
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

France Scott P.¹,Hussain Shahed¹,Hill Andrew M.¹,Hepworth Lorna J.¹,Howard Roger M.²,Mulholland Keith R.³,Flitsch Sabine L.¹,Turner Nicholas J.¹

Affiliation:

1. School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, United Kingdom

2. Pfizer Chemical Research & Development, Discovery Park House, Ramsgate Road, Sandwich CT13 9NJ, United Kingdom

3. Chemical Development, AstraZeneca, Silk Road Business Park, Macclesfield SK10 2NA, United Kingdom

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

Royal Society

Pfizer

Wolfson Foundation

Biotechnology and Biological Sciences Research Council

Centre of Excellence for Biocatalysis, Biotransformations and Biocatalytic Manufacture, University of Manchester

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.6b00855

Reference53 articles.

1. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

2. Synthesis of piperidines

3. Synthesis of Saturated N-Heterocycles

4. Direct α-Functionalization of Saturated Cyclic Amines

5. Direct sp3C–H bond activation adjacent to nitrogen in heterocycles

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