Chemoenzymatic Asymmetric Synthesis of Pregabalin Precursors via Asymmetric Bioreduction of β-Cyanoacrylate Esters Using Ene-Reductases-Reference-Cited by-同舟云学术

Chemoenzymatic Asymmetric Synthesis of Pregabalin Precursors via Asymmetric Bioreduction of β-Cyanoacrylate Esters Using Ene-Reductases

Published:2013-01-28 Issue:4 Volume:78 Page:1525-1533
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Winkler Christoph K.¹,Clay Dorina¹,Davies Simon²,O’Neill Pat²,McDaid Paul²,Debarge Sebastien²,Steflik Jeremy³,Karmilowicz Mike³,Wong John W.³,Faber Kurt¹

Affiliation:

1. Department of Chemistry, Organic & Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria

2. Pfizer Global Process Development Centre, Loughbeg, County Cork, Ireland

3. Pfizer Chemical R&D, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo302484p

Reference46 articles.

1. Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds

2. Asymmetric bioreduction of activated C=C bonds using enoate reductases from the old yellow enzyme family

3. Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases

4. Asymmetric Synthesis of O-Protected Acyloins Using Enoate Reductases: Stereochemical Control through Protecting Group Modification

5. Asymmetric Synthesis of (R)-3-Hydroxy-2-methylpropanoate (‘Roche Ester’) and Derivatives via Biocatalytic CC-Bond Reduction

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