Novel RAS Inhibitors Poricoic Acid ZG and Poricoic Acid ZH Attenuate Renal Fibrosis via a Wnt/β-Catenin Pathway and Targeted Phosphorylation of smad3 Signaling

Author:

Wang Ming1,Chen Dan-Qian1,Chen Lin1,Liu Dan1,Zhao Hui1,Zhang Zhi-Hao1,Vaziri Nosratola D.2,Guo Yan13,Zhao Ying-YongORCID,Cao Gang4

Affiliation:

1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, No. 229 Taibai North Road, Xi’an, Shaanxi 710069, China

2. Division of Nephrology and Hypertension, School of Medicine, University of California—Irvine, Irvine, California 92897, United States

3. Department of Internal Medicine, University of New Mexico, Comprehensive Cancer Center, Albuquerque, New Mexico 87131, United States

4. School of Pharmacy, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang 310053, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

General Agricultural and Biological Sciences,General Chemistry

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