Detection of Distinct Distributions of Acetaminophen and Acetaminophen-Cysteine in Kidneys up to 10 μm Resolution and Identification of a Novel Acetaminophen Metabolite Using an AP-MALDI Imaging Mass Microscope-Reference-Cited by-同舟云学术

Detection of Distinct Distributions of Acetaminophen and Acetaminophen-Cysteine in Kidneys up to 10 μm Resolution and Identification of a Novel Acetaminophen Metabolite Using an AP-MALDI Imaging Mass Microscope

Published:2023-06-12 Issue:7 Volume:34 Page:1491-1500
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Mamun Md. Al¹²^ORCID,Rahman Md. Muedur¹^ORCID,Sakamoto Takumi¹²,Islam Ariful¹²,Oyama Soho¹,Nabi Md. Mahamodun¹^ORCID,Sato Tomohito¹,Kahyo Tomoaki¹³^ORCID,Takahashi Yutaka¹²,Setou Mitsutoshi¹³⁴^ORCID

Affiliation:

1. Department of Cellular & Molecular Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan

2. Preppers Co., Ltd., Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan

3. International Mass Imaging Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan

4. Department of Systems Molecular Anatomy, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Agency for Medical Research and Development

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

https://pubs.acs.org/doi/pdf/10.1021/jasms.3c00149

Reference38 articles.

1. Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development

2. MALDI imaging mass spectrometry: bridging biology and chemistry in drug development

3. Imaging mass spectrometry in drug development and toxicology

4. A Review on Liquid Chromatography-Tandem Mass Spectrometry Methods for Rapid Quantification of Oncology Drugs

5. A review of sample preparation methods for quantitation of small-molecule analytes in brain tissue by liquid chromatography tandem mass spectrometry (LC-MS/MS)

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