High-Affinity Inhibitors of Dihydrofolate Reductase: Antimicrobial and Anticancer Activities of 7,8-Dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with Small Molecular Size-Reference-Cited by-同舟云学术

High-Affinity Inhibitors of Dihydrofolate Reductase: Antimicrobial and Anticancer Activities of 7,8-Dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with Small Molecular Size

Published:1996-01-01 Issue:4 Volume:39 Page:892-903
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kuyper Lee F.¹,Baccanari David P.¹,Jones Michael L.¹,Hunter Robert N.¹,Tansik Robert L.¹,Joyner Suzanne S.¹,Boytos Christine M.¹,Rudolph Sharon K.¹,Knick Vince¹,Wilson H. Robert¹,Caddell J. Marc¹,Friedman Henry S.¹,Comley John C. W.¹,Stables Jeremy N.¹

Affiliation:

1. Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, U.K., and Duke University Medical Center, Durham, North Carolina 27710

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9505122

Reference78 articles.

1. Dihydrofolate reductase as a therapeutic target

2. Karnofsky memorial lecture. Ode to methotrexate.

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