Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays-Reference-Cited by-同舟云学术

Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Published:2004-12-01 Issue:27 Volume:47 Page:6658-6661
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lombardo Louis J.¹,Lee Francis Y.¹,Chen Ping¹,Norris Derek¹,Barrish Joel C.¹,Behnia Kamelia¹,Castaneda Stephen¹,Cornelius Lyndon A. M.¹,Das Jagabandhu¹,Doweyko Arthur M.¹,Fairchild Craig¹,Hunt John T.¹,Inigo Ivan¹,Johnston Kathy¹,Kamath Amrita¹,Kan David¹,Klei Herbert¹,Marathe Punit¹,Pang Suhong¹,Peterson Russell¹,Pitt Sidney¹,Schieven Gary L.¹,Schmidt Robert J.¹,Tokarski John¹,Wen Mei-Li¹,Wityak John¹,Borzilleri Robert M.¹

Affiliation:

1. Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey 08543-4000

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049486a

Reference12 articles.

1. Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56Lck

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