CYP2C9 Structure−Metabolism Relationships: Optimizing the Metabolic Stability of COX-2 Inhibitors-Reference-Cited by-同舟云学术

CYP2C9 Structure−Metabolism Relationships: Optimizing the Metabolic Stability of COX-2 Inhibitors

Published:2007-08-14 Issue:18 Volume:50 Page:4444-4452
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ahlström Marie M.¹,Ridderström Marianne¹,Zamora Ismael¹,Luthman Kristina¹

Affiliation:

1. Discovery DMPK and Bioanalytical Chemistry, AstraZeneca R&D Mölndal, S-431 81 Mölndal, Sweden, Lead Molecular Design, S. L., Vallés 96-102 (27) E-08190, Sant Cugat del Vallés, Spain, Institut Municipal d'Investigació Medica (IMIM), Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Spain, and Department of Chemistry, Medicinal Chemistry, Göteborg University, SE-412 96 Gothenburg, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0705096

Reference30 articles.

1. The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

2. Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

3. Comparative Studies on the Catalytic Roles of Cytochrome P450 2C9 and Its Cys- and Leu-Variants in the Oxidation of Warfarin, Flurbiprofen, and Diclofenac by Human Liver Microsomes

4. The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0-Å Resolution

5. Crystal structure of human cytochrome P450 2C9 with bound warfarin

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