Thiazolopyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B

Author:

Kale Manoj G.,Raichurkar Anandkumar,P Shahul Hameed,Waterson David,McKinney David1,Manjunatha M. R.,Kranthi Usha,Koushik Krishna,Jena Lalit kumar,Shinde Vikas,Rudrapatna Suresh,Barde Shubhada,Humnabadkar Vaishali,Madhavapeddi Prashanti,Basavarajappa Halesha,Ghosh Anirban,Ramya VK,Guptha Supreeth,Sharma Sreevalli,Vachaspati Prakash,Kumar K.N. Mahesh,Giridhar Jayashree,Reddy Jitendar,Panduga Vijender,Ganguly Samit,Ahuja Vijaykamal,Gaonkar Sheshagiri,Kumar C. N. Naveen,Ogg Derek2,Tucker Julie A.2,Boriack-Sjodin P. Ann3,de Sousa Sunita M.,Sambandamurthy Vasan K.,Ghorpade Sandeep R.

Affiliation:

1. Chemistry, Infection iMed, AstraZeneca, Waltham, Massachusetts 02451, United States

2. Discovery Sciences, AstraZeneca, Alderley Park, Macclesfield SK10 4TF, United Kingdom

3. Biosciences, Infection iMed, AstraZeneca, Waltham, Massachusetts 02451, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference32 articles.

1. World Health Organization. Global Tuberculosis Control; WHO 2011 Report on Tuberculosis.http://www.who.int/mediacentre/news/releases/2011/tb_20111011/en/index.html

2. World Health Organization. Multidrug and Extensively Drug-Resistant TB (M/XDR-TB); WHO 2010 Global Report on Surveillance and Response.

3. Rising to the challenge: new therapies for tuberculosis

4. Delamanid improves outcomes and reduces mortality in multidrug-resistant tuberculosis

5. Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

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