Microtubule-associated protein tau is essential for long-term depression in the hippocampus-Reference-Cited by-同舟云学术

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

Published:2014-01-05 Issue:1633 Volume:369 Page:20130144
ISSN:0962-8436
Container-title:Philosophical Transactions of the Royal Society B: Biological Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. B

Author:

Kimura Tetsuya¹,Whitcomb Daniel J.²³⁴,Jo Jihoon²³,Regan Philip²⁴⁵,Piers Thomas²³⁴,Heo Seonghoo³,Brown Christopher²³,Hashikawa Tsutomu⁶,Murayama Miyuki⁶,Seok Heon²⁷,Sotiropoulos Ioannis²⁸,Kim Eunjoon⁹,Collingridge Graham L.⁴⁵¹⁰,Takashima Akihiko¹⁶,Cho Kwangwook²⁴

Affiliation:

1. Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka, Obu, Aichi 474-8522, Japan

2. Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol, Whitson Street, Bristol BS1 3NY, UK

3. Chonnam-Bristol Frontier Laboratory, Biomedical Research Institute, Chonnam National University Hospital, Gwangju 501-757, South Korea

4. Centre for Synaptic Plasticity, University of Bristol, University Walk, Bristol BS8 1TD, UK

5. School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UK

6. Laboratory for Alzheimer's Disease, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan

7. Department of Biomedical Engineering, Jungwon University, 85 Munmu-ro, Goesan-gun, Chungcheongbuk-do 367-805, South Korea

8. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, Universidade do Minho, Campus de Gualtar, Braga 710-057, Portugal

9. Center for Synaptic Brain Dysfunctions, Institute for Basic Science and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea

10. Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Gwanak-gu, Seoul 151-746, South Korea

Abstract

The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (LTD) in tau knockout mice in vivo and in vitro , an effect that was replicated by RNAi knockdown of tau in vitro . We found that the induction of LTD is associated with the glycogen synthase kinase-3-mediated phosphorylation of tau. These observations demonstrate that tau has a critical physiological function in LTD.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2013.0144

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