Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions

Author:

Keck Tara1ORCID,Toyoizumi Taro2ORCID,Chen Lu3,Doiron Brent4,Feldman Daniel E.5ORCID,Fox Kevin6,Gerstner Wulfram7,Haydon Philip G.8,Hübener Mark9,Lee Hey-Kyoung10ORCID,Lisman John E.11ORCID,Rose Tobias9ORCID,Sengpiel Frank16ORCID,Stellwagen David12ORCID,Stryker Michael P.13ORCID,Turrigiano Gina G.11,van Rossum Mark C.14ORCID

Affiliation:

1. Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK

2. RIKEN Brain Science Institute, Wako, Japan

3. Department of Neurosurgery, Stanford University, Stanford, CA, USA

4. Department of Mathematics, University of Pittsburgh, Pittsburgh, PA, USA

5. Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA

6. Division of Neuroscience, University of Cardiff, Cardiff, Wales, UK

7. Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

8. Tufts University School of Medicine, Medford, MA, USA

9. Department of Cellular and Systems Neuroscience, Max Planck Institute of Neurobiology, Martinsried, Bayern, Germany

10. The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA

11. Department of Biology, Brandeis University, Waltham, MA, USA

12. Centre for Research in Neuroscience, McGill University, Montreal, Quebec, Canada

13. Sandler Neurosciences Center, University of California, San Francisco, CA, USA

14. School of Informatics, University of Edinburgh, Edinburgh, UK

Abstract

We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next provide a synopsis of the outstanding questions that emerged from the discussion at the end of the meeting and finally suggest potential directions of research that we believe are most promising to develop an understanding of how these two forms of plasticity interact to facilitate functional changes in the brain. This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’.

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

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