Weekly COVID-19 testing with household quarantine and contact tracing is feasible and would probably end the epidemic

Author:

Peto Julian1ORCID,Carpenter James1,Smith George Davey2,Duffy Stephen3,Houlston Richard4,Hunter David J.5,McPherson Klim6,Pearce Neil1,Romer Paul7,Sasieni Peter8,Turnbull Clare4

Affiliation:

1. Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK

2. Bristol Population Health Science Institute, Bristol University, Bristol, UK

3. Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK

4. Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK

5. Nuffield Department of Population Health, Oxford University, Oxford, UK

6. New College, Oxford University, Oxford, UK

7. Stern School of Business, New York University, New York, USA

8. School of Cancer and Pharmaceutical Sciences, King's College London, London, UK

Abstract

The COVID-19 epidemic can probably be ended and normal life restored, perhaps quite quickly, by weekly SARS-CoV-2 RNA testing together with household quarantine and systematic contact tracing. Isolated outbreaks could then be contained by contact tracing, supplemented if necessary by temporary local reintroduction of population testing or lockdown. Leading public health experts have recommended that this should be tried in a demonstration project in which a medium-sized city introduces weekly testing and lifts lockdown completely. The idea was not considered by the groups whose predictions have guided UK policy, so we have examined the statistical case for such a study. The combination of regular testing with strict household quarantine, which was not analysed in their models, has remarkable power to reduce transmission to the community from other household members as well as providing earlier diagnosis and facilitating rapid contact tracing.

Publisher

The Royal Society

Subject

Multidisciplinary

Reference15 articles.

1. Covid-19 mass testing facilities could end the epidemic rapidly

2. Universal weekly testing as the UK COVID-19 lockdown exit strategy

3. Smeeth L. 2020 Should the UK really test 10 million people per day for COVID-19? https://www.lshtm.ac.uk/newsevents/expert-opinion/should-uk-really-test-10-million-people-day-covid-19 (accessed 23 May 2020).

4. Davies NG Kucharski AJ Eggo RM Gimma A CMMID COVID-19 working group Edmunds WJ. 2020 Effects of non-pharmaceutical interventions on COVID-19 cases deaths and demand for hospital services in the UK: a modelling study. Lancet Public Health . (doi:1016/S2468-2667(20)30133-X) published online 2 June 2020.

5. Ferguson NM et al. 2020 Report 9: Impact of non-pharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand. https://www.imperial.ac.uk/media/imperial-college/medicine/mrc-gida/2020-03-16-COVID19-Report-9.pdf (accessed 23 May 2020).

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