Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis-Reference-Cited by-同舟云学术

Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis

Published:2019-01 Issue:1 Volume:9 Page:180212
ISSN:2046-2441
Container-title:Open Biology
language:en
Short-container-title:Open Biol.

Author:

Chen Bing¹²^ORCID,Xia Zijing¹³,Deng Ya-Nan¹^ORCID,Yang Yanfang¹^ORCID,Zhang Peng⁴,Zhu Hongxia⁵,Xu Ningzhi¹⁵,Liang Shufang¹^ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, No. 17, 3rd Section of People's South Road, Chengdu 610041, People's Republic of China

2. Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Eastern Road, Zhengzhou 450052, People's Republic of China

3. Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China

4. Department of Urinary Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People's Republic of China

5. Laboratory of Cell and Molecular Biology and State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100034, People's Republic of China

Abstract

MicroRNAs (miRNAs) are one abundant class of small, endogenous non-coding RNAs, which regulate various biological processes by inhibiting expression of target genes. miRNAs have important functional roles in carcinogenesis and development of colorectal cancer (CRC), and emerging evidence has indicated the feasibility of miRNAs as robust cancer biomarkers. This review summarizes the progress in miRNA-related research, including study of its oncogene or tumour-suppressor roles and the advantages of miRNA biomarkers for CRC diagnosis, treatment and recurrence prediction. Along with analytical technique improvements in miRNA research, use of the emerging extracellular miRNAs is feasible for CRC diagnosis and prognosis.

Funder

Chengdu Science and Technology Program

the National Natural Science Foundation of China

the National Key Basic Research Program of China

the Health and Family Planning Commission of Sichuan Province

the Science & Technology Department of Sichuan Province

the National 863 High Tech Foundation

Publisher

The Royal Society

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology,General Neuroscience

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