Abstract
Homeostasis in vertebrates is tightly regulated by not only proliferation and differentiation of cells, but also cell death or apoptosis (Ellis
et al.
1991; Raff 1992). Many cytokines bind to their respective receptors to regulate proliferation and differentiation of cells. Our recent studies on the Fas ligand and Fas indicate that they work respectively as a death factor and its receptor and suggest that, in some cases, cell death or apoptosis is regulated by cytokines and their receptors. Here, I present the summary of the Fas/Fas ligand system which has been studied in my laboratory over the past 5 years, and I will discuss its physiological roles.
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology
Reference47 articles.
1. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.
2. Differences defined by bone marrow transplantation suggest that Ipr and gld are mutations of genes encoding an interacting pair of molecules. J. exp;Allen R.D.;Med.,1990
3. Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis. J. exp;Ando K.;Med.,1993
4. Cell-mediated cytotoxicity: contact and secreted factors
5. Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation
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