Advances in basic and translational research in atrial fibrillation

Author:

Hu Dan123ORCID,Barajas-Martinez Hector45,Zhang Zhong-He123,Duan Hong-Yi123,Zhao Qing-Yan123,Bao Ming-Wei123,Du Yi-Mei6,Burashnikov Alexander45,Monasky Michelle M.7,Pappone Carlo789,Huang Cong-Xin123,Antzelevitch Charles45,Jiang Hong123

Affiliation:

1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, People's Republic of China

2. Cardiovascular Research Institute of Wuhan University, Wuhan 430060, People's Republic of China

3. Hubei Key Laboratory of Cardiology, Wuhan 430060, People's Republic of China

4. Lankenau Institute for Medical Research, and Lankenau Heart Institute, Wynnwood, PA 19096, USA

5. Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19104, USA

6. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China

7. Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan 20097, Italy

8. Vita-Salute San Raffaele University, Milan 20132, Italy

9. Institute of Molecular and Translational Cardiology (IMTC), San Donato Milanese, Milan 20097, Italy

Abstract

Atrial fibrillation (AF) is a very common cardiac arrhythmia with an estimated prevalence of 33.5 million patients globally. It is associated with an increased risk of death, stroke and peripheral embolism. Although genetic studies have identified a growing number of genes associated with AF, the definitive impact of these genetic findings is yet to be established. Several mechanisms, including electrical, structural and neural remodelling of atrial tissue, have been proposed to contribute to the development of AF. Despite over a century of exploration, the molecular and cellular mechanisms underlying AF have not been fully established. Current antiarrhythmic drugs are associated with a significant rate of adverse events and management of AF using ablation is not optimal, especially in cases of persistent AF. This review discusses recent advances in our understanding and management of AF, including new concepts of epidemiology, genetics and pathophysiological mechanisms. We review the current status of antiarrhythmic drug therapy for AF, new potential agents, as well as mechanism-based AF ablation.This article is part of the theme issue ‘The heartbeat: its molecular basis and physiological mechanisms’.

Funder

National Institutes of Health

National Natural Science Foundation of China

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3