Catalyst-free decarboxylation of 4-hydroxycinnamic acids: efficient synthesis of 4-vinylphenols

Author:

Yang Qian1,Li Youjuan23,Liu Huanhuan23,Wang Enhua1,Peng Mei23,Deng Tingfei23,Pan Xiong23,Luo Zhongsheng23,Yan Yanfang23,Yang Lishou23,Yang Xiaosheng23ORCID

Affiliation:

1. Department of Medicine and Food, Guizhou Vocational College of Agriculture, Guiyang 550041, People's Republic of China

2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China

3. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, People's Republic of China

Abstract

We report herein an efficient protocol for the synthesis of 4-vinylphenols by a catalyst-free decarboxylation of trans -4-hydroxycinnamic acids. A variety of 4-vinylphenols has been synthesized in moderate to excellent yields. This protocol also features no polymerization.

Funder

Project of Guizhou Science and Technology Platform and Talent Team

Karst Science Research Center

Project of Engineering Center of Guizhou Provincial Development and Reform Commission

Guizhou Provincial Natural Science Foundation

National Natural Science Foundation of China

Publisher

The Royal Society

Subject

Multidisciplinary

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