Treatment activity of budesonide-loaded poly(lactic-co-glycolic acid) microspheres in infant bronchiolitis

Author:

Yu Ping1,Tian Jianhong2

Affiliation:

1. Department of Pharmacy, Medical College of Hexi University, Zhangye, Gansu, 734000, China

2. Department of Pediatric, Sun Simiao Hospital, Beijing University of Traditional Chinese Medicine, Tongchuan, Shaanxi, 727100, China

Abstract

Bronchiolitis is a common respiratory disease in infants with poor autoimmune function and narrow airways, resulting in a higher incidence. Despite great advances in medical technology, infants remain vulnerable to complications affecting the effectiveness of treatments. Therefore, suitable drug carriers for long-term local administration are the key to improve treatment efficiency. In this study, budesonide-loaded PLGA microspheres were successfully prepared by emulsification–solvent volatilization method. The microspheres had smooth and nearly spherical surfaces, and the size was 8.0–11.8 μm, with a high encapsulation rate and drug loading capacity. The slow degradation of PLGA allows enables budesonide to exert long-term and sustained effects, representing a novel method for treating infant bronchiolitis. The application value of the method for infant bronchiolitis was determined, and the relevant mechanism was explored.

Publisher

American Scientific Publishers

Subject

General Materials Science

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