Iodine-125 Seed Strand Implantation Combined with Biliary Stent for the Treatment of Malignant Obstructive Jaundice

Abstract

Extrahepatic or intrahepatic bile duct stenosis and obstruction can lead to malignant obstructive jaundice (MOJ). Surgical treatment is an effective method, but for patients who cannot undergo surgery or miss the opportunity for surgery, biliary stent combined with 125I implantation can improve obstruction symptoms, relieve biliary obstruction, and improve liver function. This study was to investigate the efficacy of 125I implantation, single biliary stent and percutaneous transhepatic drainage (PTCD) in the treatment of MOJ. 107 patients with MOJ were included. Thirty-seven patients (study group) received biliary stent implantation of 125I particle radiotherapy drainage tube, and 35 patients (sem group) received biliary stent implantation of ordinary drainage tube. 35 patients (PTCD group) underwent PTCD interventional surgery. Biliary stenosis site, Child-Pugh grade and malignant tumor were recorded in the three groups. The changes of liver function before and after treatment were detected, and the survival time, stent patency time, and the occurrence of complications were recorded. All three groups achieved technical success. Liver function was improved in all patients (TBIL, DBIL and ALT were significantly decreased, and P values were all less than 0.05). This study demonstrates that 125I seed beam implantation combined with biliary stent implantation can be considered a safe treatment option for patients with MOJ. This treatment can improve median overall survival, improve liver function, prolong stent patency time.