A Nanofibrous Neural Channel Combined with a Passive and Active Exercise Improve Muscle Re-Innervation in a Rat Model of Sciatic Nerve Injury: An <i>In Vitro</i> and <i>In Vivo</i> Study-Reference-Cited by-同舟云学术

A Nanofibrous Neural Channel Combined with a Passive and Active Exercise Improve Muscle Re-Innervation in a Rat Model of Sciatic Nerve Injury: An In Vitro and In Vivo Study

Published:2023-06-01 Issue:6 Volume:19 Page:1027-1035
ISSN:1550-7033
Container-title:Journal of Biomedical Nanotechnology
language:en
Short-container-title:j biomed nanotechnol

Author:

Chen Ji¹,Wang Lijun²,Sun Jinliang³,Tang Yuanjin⁴,Ren Bo⁵

Affiliation:

1. Sports Department, Zhejiang Yuexiu University, Shaoxing, 312000, Zhejiang, China

2. International College, Krirk University, Bangkok, 10220, Thailand

3. Department of Public Physical, Changchun Humanities and Sciences College, Changchun, 130117, Jilin, China

4. College of Physical Education and Health, Yulin Normal University, Yulin, 537000, Guangxi, China

5. School of Economics and Management Shanghai University of Sport, Shanghai, 200438, China

Abstract

In the current study, we compared the effects of passive (bicycle) and active (treadmill) exercise combined with an electrospun crocetin-loaded neural conduits on sciatic nerve repair in a rat model. The animals were treated with a nanofibrous neural conduit and received regular excesses. Study showed that the animals treated with both exercise and neural conduits had significantly higher SFI values and better response to painful stimulus. In addition, gastrocnemius muscle re-innervation was significantly better in the crocetin-loaded conduits+exercise group.

Publisher

American Scientific Publishers

Subject

Pharmaceutical Science,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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