Moderate Treadmill Exercise Improves Spinal Cord Injury Repair Administered with Carica Papaya Leaf Extract-Loaded Nanocomposite Hydrogel
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Published:2023-03-01
Issue:3
Volume:19
Page:488-495
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ISSN:1550-7033
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Container-title:Journal of Biomedical Nanotechnology
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language:en
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Short-container-title:j biomed nanotechnol
Author:
Sun Shiwei1,
Zhang Tianlong1,
Zhou Wuling1,
Huang Haitian1,
Wang Minghai1,
Lyu Feizhou1
Affiliation:
1. Shanghai Fifth People’s Hospital, Fudan University, Shanghai, 200240, China
Abstract
In the current research, spinal cord injury was repaired through a moderate treadmill exercise and carica papaya leaf extract-loaded nanocomposite hydrogel. In vitro studies showed that the carica papaya extract-loaded nanocomposite hydrogel augmented the metabolic function of
the cells and showed a gradual degradation. In vivo study showed that the developed treatment strategy promoted spinal cord injury repair as shown in histopathological studies and BBB assay.
Publisher
American Scientific Publishers
Subject
Pharmaceutical Science,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering