Novel Combinatorial Dexamethasone and Hyaluronic Acid Micro Particulate Injection for the Treatment of Hip Arthritis: Assesment in Rabbit Model
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Published:2021-01-01
Issue:1
Volume:11
Page:123-128
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ISSN:2157-9083
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Container-title:Journal of Biomaterials and Tissue Engineering
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language:en
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Short-container-title:j biomater tissue eng
Author:
Ma Shiqiang1,
Guo Donghui1,
Shi Qiuling1,
Li Xiaoming1
Affiliation:
1. The Third Departments of Bone and Joint Surgery, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine of Hebei Province, Cangzhou City, Hebei Province, 061000, China
Abstract
The aforementioned study emphasis on formulation of Dexamethasone and Hyaluronic acid (DHA) loaded microspheres for intra-articulate injection at hip region to cure arthritic condition. DHA microspheres were formulated by solvent evaporation technique. The microspheres were found with
smooth, regular surface characteristics. The loading and encapsulation efficiencies were also found higher. The in vitro release was found to be 15.12% for initial 24 hrs while 97.65% up to 25 days. Such microspheres were injected to hip region of Adult male new Zealand Rabbits (2.5–3
kg) to observe anti arthritic effect. The study result showed excellent ability of microsphere in order to treat arthritis. Therefore the results obtained concluded effectiveness of DHA microspheres in treating arthritic disease.
Publisher
American Scientific Publishers
Subject
Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology