Cancer Exosome Loaded with Paclitaxel for Targeted Lung Cancer Therapy-Reference-Cited by-全球学者库

Cancer Exosome Loaded with Paclitaxel for Targeted Lung Cancer Therapy

Published:2023-01-01 Issue:1 Volume:13 Page:118-122
ISSN:2157-9083
Container-title:Journal of Biomaterials and Tissue Engineering
language:en
Short-container-title:j biomater tissue eng

Author:

Sun Zhengui¹,Zang Leilei¹,Cheng Yusheng¹,Qin Lilong¹

Affiliation:

1. Department of Respiratory and Critical Care Medicine, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui, 241001, China

Abstract

Lung cancer is a serious issue to threat the health of human and the treatment using currently available chemotherapy drug, such as paclitaxel (PTX) is significantly impaired by the poor solubility and targetability. In this study, we used the cancer exosome (CE) derived from lung cancer cell line A549 to load PTX (CE/PTX) and construct a drug delivery system (DDS) for the treatment of A549 tumor in a mice mode. The DDS realized better inhibition on both A549 cells and tumors as compared to commercial PTX formulation (Taxol). Therefore, we believe this strategy can be applied to clinical trials for better cancer treatment.

Publisher

American Scientific Publishers

Subject

Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology

Reference13 articles.

1. Focus on lung cancer;Minna;Cancer Cell,2002

2. The effect of advances in lung-cancer treatment on population mortality;Howlader;New England Journal of Medicine,2020

3. Olean-28, 13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways;Zhu;Biochem. Pharmacol.,2019

4. Piperlongumine inhibits Akt phosphorylation to reverse resistance to cisplatin in human non-small cell lung cancer cells via ROS regulation;Zhang;Frontiers in Pharmacology,2019

5. Triple combination of heat, drug and radiation using alginate hydrogel co-loaded with gold nanoparticles and cisplatin for locally synergistic cancer therapy;Mirrahimi;Int. J. Biol. Macromol.,2020

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