Precise engineering of silver loaded polyvinyl alcohol nanogels for wound nursing care systems in operation room

Abstract

This study was designed to establish the composition of wound bandages based on silver nanoparticle (AgNP)loaded polyvinyl alcohol (PVA) nanogels. The AgNP nanogel (Ag-nGel) was fabricated by the fructose-mediated reduction of silver nitrate solutions within the PVA matrix. The influence of different experimental limitations on PVA nanogel formations were examined. The nanogel particle sizes were evaluated by transmission electron microscopy and determined to range from ∼10–50 nm. Additionally, glycerol were added to the Ag-nGels, and the resulting compositions (Ag-nGel-Glu) were coated on cotton fabrics to generate the wound bandaging composite. The cumulative drug release profile of the silver from the bandage was found to be ∼38% of the total loading after two days. Additionally, antibacterial efficacy was developed for gram positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 21 days. In contrast to the untreated wounds, rapid healing was perceived in the Ag-nGel-Glu-treated wound with less damaging. These findings indicate that Ag-nGel-Glu-based bandaging materials could be a potential candidate for wound bandaging applications in the future.