A preliminary study on the application of paramagnetic composite nanoparticles in the navigation of hepatectomy

Abstract

As the preferred treatment strategy for primary liver cancer, hepatic resection surgery can effectively improve the survival of liver cancer patients without relying on other treatments. However, traditional hepatic resection surgery cannot achieve precise localization of the cancer foci boundary. Therefore, improving hepatectomy targeting and reducing the metabolic rate of contrast agents in vivo has become an urgent challenge. This study constructed a novel indocyanine green nanocomposite fluorescent contrast agent, known as indocyanine green-carboxymethyl chitosan/superparamagnetic iron oxide nanoparticle (ICG-CMCS/SIO NP), based on a superparamagnetic iron oxide. The carboxymethyl chitosan and indocyanine green (ICG)’s graft copolymer served as a nanomaterial shell. This shell enhanced ICG targeting’s control ability and stability while effectively retaining its core magnetic properties. Thus, ICG-CMCS/SIO NPs should provide a novel idea for the study of clinical hepatocellular carcinoma resection surgery navigation.