Preparation, Characterization, and Bioactivities of Cobalt, Strontium and Fluorine Co-Doped Oxide Films on Titanium Surface for Clinical Application

Author:

Wu Xinglin1,Jiao Yang2,Wu Jieshi3,Zhang Sujiajun3,Xu Ruisheng3,Zhao Quanming1,Lu Kaihang1,Zhang Pengpeng1,Zhang Lu4,Ni Xiaohui4

Affiliation:

1. Department of Orthopedics, Guizhou Provincial People’s Hospital, Guiyang, 550002, Guizhou, China

2. Department of Stomatology, The Seventh Medical Center of PLA General Hospital, Beijing 100700, China

3. Department of Orthopedics, Affiliated Hospital of Jiangnan University, Wuxi, 214000, Jiangsu, China

4. Department of Orthopedics, Dafeng People’s Hospital, Yancheng, 224100, Jiangsu, China

Abstract

Titanium and titanium alloys are receiving widespread attention due to their excellent comprehensive mechanical properties, corrosion resistances, and biocompatibilities. However, titanium metal itself is biologically inert in physiological environments, and after implantation, it is surrounded by a layer of encapsulating fibrous membrane, making it difficult to form solid bonds with the tissue. Plasma electrolytic oxidation is a new technology used to prepare bioactive porous ceramic membranes on the surfaces of titanium and titanium alloys. It has application prospects for biomimetic surface modifications of titanium alloys. In this study, a cobalt, strontium and fluorine codoped oxide film (TAM-CSF) was prepared on a titanium surface via plasma electrolytic oxidation. The surface characteristics of the film were evaluated with field emission scanning electron microscopy, energy spectrum analyses, atomic force microscopy, profilometry and X-ray photoelectron spectroscopy. Additionally, the corrosion performance of the material was evaluated with an electrochemical workstation. The biocompatibility and bioactivity of the film were tested with in vitro cell experiments. The results showed that the TAM-CSF on the titanium surface had a porous morphology, and the CSF was uniformly doped on the film surface. TAM-CSF improved the surface roughness of the titanium. This film exhibited good biocompatibility and promoted the extension and proliferation of MC3T3-E1 cells. It was possible to prepare TAM-CSF on titanium surfaces via plasma electrolytic oxidation. The film exhibited a good morphology and good biological activity and has clinical application prospects.

Publisher

American Scientific Publishers

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