Nanoparticle contrast technology-based protective effects of amiodarone catheter perfusion on cardiac injury caused by radiofrequency ablation

Abstract

Radiofrequency ablation can damage the cardiac tissues and affect their functions. Amiodarone is a commonly used antiarrhythmic drug that protects the heart tissues. This study used nanoparticle contrast technology to explore the protective effects of amiodarone catheter perfusion on cardiac injury caused by radiofrequency ablation. The model of atrial fibrillation (AF) was established in healthy piglets. All piglets were subjected to three-dimensional heart reconstruction with nano-computed tomography (CT) before surgery, followed by radiofrequency ablation. Subsequently, the random number table method divided them into experimental (four piglets) and control groups (four piglets). The experimental group was treated with amiodarone catheter infusion, and the control group was the amiodarone non-intervention group. The changes in serum myoglobin (Mb), troponin I (cTnI), and creatine kinase isoenzyme (CK-MB) in the two groups before an operation, 6 h, 12 h, and 48 h after the operation, were analyzed. The degree of injury of right atrial radiofrequency ablation was analyzed and compared between the two groups. The total time and the number of radiofrequency ablation discharges were recorded. After 12 h of radiofrequency ablation, the levels of Mb and CK-MB in the pigs’ serum increased (P <0.05). The levels of cTnI increased 12 h after surgery (P <0.01) and became normal 48 h after surgery. The depth and width of right atrial heart tissue injury, Mb, CK-MB, and cTnI in the experimental group were significantly lower than in the control group. After treatment, the left ventricular ejection fraction (LVEF) and cardiac index (CI) in the two groups were higher, while the left ventricular end-systolic volume (LVESV) was lower than those before treatment. The LVEF and CI in the experimental group were higher, and LVESV was lower than those in the control group. The myocardial injury caused by radiofrequency ablation is a minor myocardial injury, which can increase the serum myocardial damage markers to varying degrees; CK-MB, cTnI, and Mb can be used for radiofrequency catheter ablation monitoring of myocardial injury. Amiodarone catheter perfusion produces protective effects on cardiac injury caused by radiofrequency ablation. This study provides a new therapeutic method for cardiac injury caused by radiofrequency ablation.