Synthesis, biological evaluation and molecular docking studies of novel mixed-ligand Schiff base/8-hydroxyquinoline metal complexes

Abstract

Five manufactured mixed ligands chelate of Schiff base (HL) in the presence of 8-hydroxyquinoline (HQ) with Chromium(III), Cobalt(II), Silver(I) tin(II), and mercury(II) was produced and described. The molecular structure of complexes was examined using physicochemical analysis, thermogravimetric analysis, and spectroscopic methods. Measurements of morphological properties confirm the nano-crystalline particles of the fabricated chelates. FT-IR analysis revealed that HL and HQ chelated with metal ions as NO bi-dentate ligands. The synthesized complexes have distorted octahedral (Cr(III) and Co(II)) and tetrahedral (Ag(I), Sn(II), and Hg(II) forms, according to magnetic and electronic spectrum data. Thermogravimetric (TG) analysis indicates that the formation complexes were stable. The antimicrobial and antiviral effectiveness of ligands and their metal complexes has also been investigated. The results indicated that the newly prepared complexes were greater in activity in contrast to their free ligands, and Studies on molecular docking have been performed out in order to determine the optimal engagement location as well as its inhibitory activity.