Aggregation-Induced Emission-Based Vaccine Improves Potential Antitumor Immunotherapy-Reference-Cited by-同舟云学术

Aggregation-Induced Emission-Based Vaccine Improves Potential Antitumor Immunotherapy

Published:2021-10-01 Issue:10 Volume:17 Page:2053-2061
ISSN:1550-7033
Container-title:Journal of Biomedical Nanotechnology
language:en
Short-container-title:j biomed nanotechnol

Author:

Liang Yong¹,Gong Huanle²,Li Yan³,Lu Yinghao³,Wu Xiaoqian¹,Zhang Xiaoyan⁴,Ding Dan⁴,Tang Xiaolong⁵,Tang Qiyun⁶

Affiliation:

1. Central and Clinical Laboratory, The Affiliated Huaian Hospital of Xuzhou Medical University and Huaian Second Hospital, Huaian, 223002, China

2. Institute of Blood and Marrow Transplantation, Medical College of Soochow University, Soochow University, Collaborative Innovation Center of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China

3. Department of Hematology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550004, China

4. State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Tianjin, 300071, China

5. Key Laboratory of Industrial Dust Prevention and Control and Occupational Safety and Health of the Ministry of Education, Anhui University of Science & Technology, Huainan, 232001, China

6. Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

Abstract

Recently, immunomodulation based on biomaterials has held great promise for preventing and treating cancer. Tumor vaccination can be considered as one of promising immunotherapies, compared with the vaccines for infectious disease, it still stays in its infant. Herein, we designed a near-infrared-emitting AIEgens (named TPE-Ph-DCM) based vaccine as an adjuvant in enhancing immune response. AIE-based photodynamic vaccine exhibited efficiently enhancement of the DC?s antigen prestation and elicited antigen-specific cytotoxic T lymphocyte functionality, and significantly inhibited B16-OVA tumor growth prophylactically and therapeutically in mice model. This study is expected to provide a scientific basis for developing effective and safe tumor vaccines.

Publisher

American Scientific Publishers

Subject

Pharmaceutical Science,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering